Dr. Eliezer M. Van Allen and CBIIT’s Dr. Jill Barnholtz-Sloan kick off the first of nine seminars in a series designed for data scientists interested in the latest data science technologies and immunotherapy research.

Dr. Malachi Griffith will give an introduction to neoantigens, a promising area for cancer immunotherapy and precision medicine. Dr. Griffith will describe how immunogenomic and bioinformatic approaches are helping to identify neoantigens and therapeutic modalities to target these abnormal proteins. He also will offer insight into tools to support related clinical trial efforts.

At the April NCI Imaging and Informatics Community Webinar, Dr. Maryellen L. Giger will discuss the development, validation, database needs, and future implementation of artificial intelligence in the clinical radiology workflow, which will include case studies on breast cancer and COVID-19 data.

At the upcoming Cancer Genomics Cloud (CGC) webinar, Ms. Trudy Zou, a University of Pittsburgh medical student, will present on behalf of her peers at Musculoskeletal Oncology Laboratory how they used the CGC to identify genomic alterations in a rare musculoskeletal tumor called “extraskeletal myxoid chondrosarcoma.”

Dr. Ben Raphael will describe how tumors are heterogeneous mixtures of normal and cancerous cells with distinct genetic and transcriptional profiles. He’ll also discuss computational approaches to quantify tumor heterogeneity and reconstruct tumor evolution using data from single-cell DNA and spatial RNA sequencing technologies.

NIH’s Office of Data Science Strategy’s Innovation Lab, “A Data Ecosystems Approach to Ethical AI for Biomedical and Behavioral Research,” will examine systems-wide solutions for defining and addressing the ethical concerns that may arise in AI and data research. Apply by 5:00 p.m. ET, February 14, 2022.

Dr. Enis Afgan will provide an overview of Galaxy and its increasing use of software containers to ensure consistency and promote software portability. This webinar will explore what goes on behind the scenes to make a Galaxy installation function at scale.

If you’re a cancer researcher looking to learn about the upcoming and required NIH data management and data sharing plan mandates, don’t miss this webinar exploring the ELIXIR RDMkit, a framework for advice and best practices regarding research data management.

Dr. Elana J. Fertig (whose lab also uses multiplatform genomics data, blended with mathematical modeling and artificial intelligence) will demonstrate how CoGAPS, an established method for identifying transcriptional signatures related to cell type and state, can be applied to single cell data to identify patterns underlying immunotherapy response and resistance. Combining CoGAPS with transfer learning approaches provides insight into the patterns found in preclinical models, which then can be applied to patient samples to find shared features across data sets from different species.

In this installment of the NCI Imaging and Informatics Community Webinar, learn about the impending challenges and different approaches for detecting and mitigating bias when implementing clinical artificial intelligence (AI) and machine learning (ML) algorithms within a clinical setting. Dr. Issam El Naqa of the Moffitt Cancer Center will give examples of how to apply these approaches in oncology applications and discuss their implications to pave the way for AI/ML in clinical practice.