Jill Barnholtz-Sloan, Ph.D.
Associate Director for Informatics and Data Science
Contact Information
Organization
Biography
As the Associate Director for Informatics and
Dr. Barnholtz-Sloan is a nationally and internationally recognized leader in the fields of cancer informatics and data science. As principal investigator of the Ohio Brain Tumor Study, a multi-site tissue source for The Cancer Genome Atlas and the Central Brain Tumor Registry for the United States (CBTRUS), she knows the challenges researchers face when collecting, integrating, analyzing, and sharing the full range of complex, multi-scale data in use today.
While at Case Western Reserve and University Hospitals Health System, she was the Sally S. Morley Designated Professor in Brain Tumor Research; associate director, Data Sciences at the Case Comprehensive Cancer Center; associate director, Translational Informatics, Cleveland Institute for Computational Biology; and director, Research Health Analytics and Informatics. This experience has given her a clear understanding of the administrative side of managing large, complex data sets. She’s successfully navigated issues related to data access, security, and privacy; and she’s implemented measures to make it easier for researchers to use data in ways that yield meaningful results.
Dr. Barnholtz-Sloan is renowned in the field. She serves or has served on national and international advisory boards and committees for numerous brain tumor foundations, study sections, and consortia. She is an associate editor for multiple peer-reviewed journals, including Neuro-Oncology, Journal of Neuro-Oncology, and JCO Cancer Clinical Informatics.
She received her doctorate in biostatistics from the University of Texas Health Science Center at Houston School of Public Health, a master’s degree in statistics from the University of Texas at Austin, and a bachelor’s degree in mathematics from the University of Florida.
Projects
- Cancer Moonshot℠
- Childhood Cancer Data Initiative (CCDI)
- Imaging Data Commons
- NCI Cancer Research Data Commons (CRDC)
- NCI Data Commons Framework
Selected Publications
See a full list of publications.
- Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, Rykunov D, Colaprico A, Rothstein JH, Hong R, Stathias V, Cornwell M, Petralia F, Wu Y, Reva B, Krug K, Pugliese P, Kawaler E, Olsen LK, Liang WW, Song X, Dou Y, Wendl MC, Caravan W, Liu W, Cui Zhou D, Ji J, Tsai CF, Petyuk VA, Moon J, Ma W, Chu RK, Weitz KK, Moore RJ, Monroe ME, Zhao R, Yang X, Yoo S, Krek A, Demopoulos A, Zhu H, Wyczalkowski MA, McMichael JF, Henderson BL, Lindgren CM, Boekweg H, Lu S, Baral J, Yao L, Stratton KG, Bramer LM, Zink E, Couvillion SP, Bloodsworth KJ, Satpathy S, Sieh W, Boca SM, Schürer S, Chen F, Wiznerowicz M, Ketchum KA, Boja ES, Kinsinger CR, Robles AI, Hiltke T, Thiagarajan M, Nesvizhskii AI, Zhang B, Mani DR, Ceccarelli M, Chen XS, Cottingham SL, Li QK, Kim AH, Fenyö D, Ruggles KV, Rodriguez H, Mesri M, Payne SH, Resnick AC, Wang P, Smith RD, Iavarone A, Chheda MG, Barnholtz-Sloan JS, Rodland KD, Liu T, Ding L; Clinical Proteomic Tumor Analysis Consortium. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell. 2021 Apr 12;39(4):509-528.e20. doi: 10.1016/j.ccell.2021.01.006. Epub 2021 Feb 11. PMID: 33577785
- Rathore S, Mohan S, Bakas S, Sako C, Badve C, Pati S, Singh A, Bounias D, Ngo P, Akbari H, Gastounioti A, Bergman M, Bilello M, Shinohara RT, Yushkevich P, O'Rourke DM, Sloan AE, Kontos D, Nasrallah MP, Barnholtz-Sloan JS, Davatzikos C. Multi-institutional noninvasive in vivo characterization of IDH, 1p/19q, and EGFRvIII in glioma using neuro-Cancer Imaging Phenomics Toolkit (neuro-CaPTk). Neurooncol Adv. 2021 Jan 23;2(Suppl 4):iv22-iv34. doi: 10.1093/noajnl/vdaa128. eCollection 2020 Dec. PMID: 33521638 Free PMC article.
- Forjaz G, Barnholtz-Sloan JS, Kruchko C, Siegel R, Negoita S, Ostrom QT, Dickie L, Ruhl J, Van Dyke A, Patil N, Cioffi G, Miller KD, Waite K, Mariotto AB. An updated histology recode for the analysis of primary malignant and nonmalignant brain and other central nervous system tumors in the Surveillance, Epidemiology, and End Results Program. Neurooncol Adv. 2020 Dec 8;3(1):vdaa175. doi: 10.1093/noajnl/vdaa175. eCollection 2021 Jan-Dec. PMID: 33506208 Free PMC article.
- Patil N, Kelly ME, Yeboa DN, Buerki RA, Cioffi G, Balaji S, Ostrom QT, Kruchko C, Barnholtz-Sloan J. Epidemiology of Brainstem High-Grade Gliomas in Children and Adolescents in the United States, 2000-2017. Neuro Oncol. 2020 Dec 21:noaa295. doi: 10.1093/neuonc/noaa295. Online ahead of print. PMID: 33346835
- Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017. Neuro Oncol. 2020 Oct 30;22(12 Suppl 2):iv1-iv96. doi: 10.1093/neuonc/noaa200. PMID: 33123732
- Johansen ML, Stetson LC, Vadmal V, Waite K, Berens ME, Connor JR, Lathia J, Rubin JB, Barnholtz-Sloan JS. Gliomas display distinct sex-based differential methylation patterns based on molecular subtype. Neurooncol Adv. 2020 Jan 8;2(1):vdaa002. doi: 10.1093/noajnl/vdaa002. eCollection 2020 Jan-Dec.PMID: 32642674 Free PMC article.
- Hanauer DA, Barnholtz-Sloan JS, Beno MF, Del Fiol G, Durbin EB, Gologorskaya O, Harris D, Harnett B, Kawamoto K, May B, Meeks E, Pfaff E, Weiss J, Zheng K. Electronic Medical Record Search Engine (EMERSE): An Information Retrieval Tool for Supporting Cancer Research. JCO Clin Cancer Inform. 2020 May;4:454-463. doi: 10.1200/CCI.19.00134. PMID: 32412846
- Dong M, Cioffi G, Wang J, Waite KA, Ostrom QT, Kruchko C, Lathia JD, Rubin JB, Berens ME, Connor J, Barnholtz-Sloan JS. Sex Differences in Cancer Incidence and Survival: A Pan-Cancer Analysis. Cancer Epidemiol Biomarkers Prev. 2020 Jul;29(7):1389-1397. doi: 10.1158/1055-9965.EPI-20-0036. Epub 2020 Apr 29. PMID: 32349967
- Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2020 Aug 17;22(8):1073-1113. doi: 10.1093/neuonc/noaa106. PMID: 32328653 Free PMC article. Review.
- Touat M, Li YY, Boynton AN, Spurr LF, Iorgulescu JB, Bohrson CL, Cortes-Ciriano I, Birzu C, Geduldig JE, Pelton K, Lim-Fat MJ, Pal S, Ferrer-Luna R, Ramkissoon SH, Dubois F, Bellamy C, Currimjee N, Bonardi J, Qian K, Ho P, Malinowski S, Taquet L, Jones RE, Shetty A, Chow KH, Sharaf R, Pavlick D, Albacker LA, Younan N, Baldini C, Verreault M, Giry M, Guillerm E, Ammari S, Beuvon F, Mokhtari K, Alentorn A, Dehais C, Houillier C, Laigle-Donadey F, Psimaras D, Lee EQ, Nayak L, McFaline-Figueroa JR, Carpentier A, Cornu P, Capelle L, Mathon B, Barnholtz-Sloan JS, Chakravarti A, Bi WL, Chiocca EA, Fehnel KP, Alexandrescu S, Chi SN, Haas-Kogan D, Batchelor TT, Frampton GM, Alexander BM, Huang RY, Ligon AH, Coulet F, Delattre JY, Hoang-Xuan K, Meredith DM, Santagata S, Duval A, Sanson M, Cherniack AD, Wen PY, Reardon DA, Marabelle A, Park PJ, Idbaih A, Beroukhim R, Bandopadhayay P, Bielle F, Ligon KL. Mechanisms and therapeutic implications of hypermutation in gliomas. Nature. 2020 Apr;580(7804):517-523. doi: 10.1038/s41586-020-2209-9. Epub 2020 Apr 15. PMID: 32322066