Somatic Variant Analysis and Detection Using Localized Genome Graphs

November 29, 2023 11:00 a.m. - 12:00 p.m. ET

In this seminar, you'll learn about the somatic variant caller named Lancet. This accurate, open-source tool leverages local assembly and joint analysis of tumor-normal, paired, high-throughput sequence data.

New York Genome Center’s Dr. Giuseppe Narzisi will provide an overview of:

  • the methodology behind the tool.
  • how it’s benchmarking against similar tools.
  • improvements in computational performance.
  • recent integrations with third party tools to visually inspect the somatic variants in graph space.

Dr. Narzisi will also give a historical review of alignment-based methods. He’ll highlight limitations and the need for new genome graph approaches.

The Data Science Seminar Series presents talks from innovators in the cancer research and informatics communities both within and outside of NCI.

Giuseppe Narzisi, Ph.D.

Dr. Narzisi is the associate director of computational biology at the New York Genome Center, where he leads a group of scientists, programmers, and engineers conducting genomics research and methods development. He is an NCI ITCR investigator, and he’s a recipient of the “IBM Ph.D. Fellowship Award” for his innovative research in Computational Genomics. His research interest is in developing novel algorithms and computational systems to analyze DNA sequences, concentrating on the assembly and alignment of next generation sequencing reads.

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