Somatic Variant Analysis and Detection Using Localized Genome Graphs
In this seminar, you'll learn about the somatic variant caller named Lancet. This accurate, open-source tool leverages local assembly and joint analysis of tumor-normal, paired, high-throughput sequence data.
New York Genome Center’s Dr. Giuseppe Narzisi will provide an overview of:
- the methodology behind the tool.
- how it’s benchmarking against similar tools.
- improvements in computational performance.
- recent integrations with third party tools to visually inspect the somatic variants in graph space.
Dr. Narzisi will also give a historical review of alignment-based methods. He’ll highlight limitations and the need for new genome graph approaches.
The Data Science Seminar Series presents talks from innovators in the cancer research and informatics communities both within and outside of NCI.
Dr. Narzisi is the associate director of computational biology at the New York Genome Center, where he leads a group of scientists, programmers, and engineers conducting genomics research and methods development. He is an NCI ITCR investigator, and he’s a recipient of the “IBM Ph.D. Fellowship Award” for his innovative research in Computational Genomics. His research interest is in developing novel algorithms and computational systems to analyze DNA sequences, concentrating on the assembly and alignment of next generation sequencing reads.
Upcoming Events
- Live Demo: National Childhood Cancer Registry (NCCR) Data PlatformNovember 12, 2024Integrating AI and Generative AI in Operations and Research: From Creating the Team and Infrastructure to Supporting 2,000+ UsersNovember 13, 2024Federated AI in Training Prediction Models: AI in Immuno-oncologyNovember 13, 2024Tenth Computational Approaches for Cancer Workshop 2024 (CAFCW24)November 18, 202429th Annual Meeting and Education Day of the Society for Neuro-Oncology (SNO)November 21, 2024 - November 24, 2024Evaluating AI Models: Benchmarking and FairnessNovember 26, 2024