Mutational Epidemiology of Childhood Cancer

Join the Childhood Cancer Data Initiative (CCDI) community for a webinar exploring the mutational epidemiology of childhood cancer, a new frontier in understanding risk factor associations.

In adult cancers, it has long been known that associations of epidemiologic risk factors can differ by driver mutation, a phenomenon called “etiologic heterogeneity.” More recently, two “motograph” publications on kidney cancer and young onset colorectal cancer have demonstrated that passenger mutations—most notably, the signatures of mutational processes (MutSig)—vary widely across place.

Thanks to multiple efforts by the National Institutes of Health—including the CCDI Molecular Characterization Initiative (MCI), the Gabriella Miller Kids First Pediatric Research Program, and the Molecular Profiling to Predict Response to Treatment (MP2PRT) program—we are now beginning to articulate the mutational epidemiology of childhood cancer. This webinar will discuss data sources and methods of analysis for childhood cancer tumor data and present preliminary risk factor associations with molecular subtypes and MutSig in acute lymphoblastic leukemia (MP2PRT) and ependymoma (MCI).

If you are an individual with a disability who needs reasonable accommodations to participate in this event, please email CCDIevents@mail.nih.gov by August 5, 2025.

This webinar is part of the CCDI webinar series, which highlights how to use CCDI’s web applications, platforms, and data, and gives attendees the opportunity to learn how to use available resources. Webinars will be recorded and made available for viewing post-event.

For more information about CCDI events, including past event recordings, visit our Events & Webinars page.