Interoperating Cloud Platforms to Survey the Baseline for LINE-1 Expression in Non-Tumor Tissues
This month’s Cancer Genomics Cloud (CGC) webinar welcomes Dr. Wilson McKerrow from the NYU Grossman School of Medicine to discuss how he leveraged the CGC to baseline the presence of LINE-1 expression in non-tumor tissues.
LINE-1 retrotransposons are genomic sequences that can copy and insert themselves in the genome, contributing to genome instability seen in cancer. While researchers have heavily studied LINE-1 activity in tumors, the baseline expression in non-tumor tissues is not well understood. In this upcoming webinar, Dr. McKerrow will discuss his LINE-1 research in collaboration with Seven Bridges through linking RNA-seq data from GTEx to his L1EM tool on the CGC to survey LINE-1 expression outside the context of cancer.
As one of the three Cloud Resources within the NCI Cancer Research Data Commons, the Seven Bridges’ CGC provides researchers access to a wide variety of data sets, a catalog of tools to analyze and visualize the data directly from the browser, and scalable computational resources to perform large-scale analysis on the cloud.
Dr. McKerrow is a postdoctoral fellow working with Drs. David Fenyö and Jef Boeke at the NYU Grossman School of Medicine. His research focuses on the regulation of retrotransposons and their rules in human diseases, especially cancer.