Computational and Mathematical Approaches to Modeling Immunotherapy-Radiotherapy Combinations
During this seminar, Dr. Clemens Grassberger will highlight:
- current computational and mathematical approaches for modeling the impact of radiotherapy on the immune system, and
- how to design the next generation of combination trials.
The increasing use of radiotherapy in multi-modality approaches, together with targeted biological agents, have emphasized the need for treatment response models encompassing the entire cancer treatment, not only radiotherapy. When combining radiotherapy with immunotherapeutic approaches, there is now a focus on evaluating the effects of radiation on the patient’s immune response, in addition to the direct biological effects of radiation on the tumor.
The Data Science Seminar Series presents talks from innovators in the cancer research and informatics communities both within and outside of NCI.
Dr. Grassberger is the head of the radiation-drug treatment design lab and an assistant professor at Harvard Medical School. He has his MSc in Physics from Eidgenössische Technische Hochschule in Zürich, Switzerland. Dr. Grassberger’s top areas of specialty include exploring rational combinations between various immunotherapeutic approaches and radiotherapy; lymphocyte cell populations as markers of treatment response; and modeling interactions of biological agents and chemotherapy with radiation.