HLA Class II Across The Cancer Genome Atlas Cancer Dataset

Wrapping up its final webinar of 2021, the NCI Cancer Research Data Commons (CRDC) Cancer Genomics Cloud (CGC) welcomes Cold Spring Harbor Laboratory fellow Dr. Pascal Belleau. He will share his findings from recent work on the CGC, typing the Human Leukocyte Antigen (HLA) class II complex in 11,000 patient samples from The Cancer Genome Atlas (TCGA) data set.

Through his study, Dr. Belleau investigated the presence and patterns of the HLA class II complex across 33 tumor types. The HLA class II complex is a molecular component linked to the body’s immune response. Understanding how this molecular complex differs across cancer types can give us insight into how it may mediate the immune system’s response to cancer.

As one of the three Cloud Resources within the NCI CRDC, the Seven Bridges’ CGC provides researchers access to a wide variety of data sets, a catalog of tools to analyze and visualize the data directly from the browser, and scalable computational resources to perform large scale-analysis in the cloud.