HLA-Arena: Enabling Structure-Guided Pipelines for Personalized Cancer Immunotherapy Design
Are you interested in learning about the role of Human Leukocyte Antigens (HLA) in cancer? Join Dr. Dinler Antunes of the University of Houston as he presents the HLA-Arena tool—a computational platform that incorporates neoantigen markers and other bioinformatics pipelines to study HLA in cancer.
The HLA-Arena 2.0 environment integrates existing neoantigen discovery resources, such as pVACtools, with new AI-driven bioinformatics methods to help you predict immunogenicity, off-target toxicity, and T-cell receptor (TCR) specificity.
By leveraging structural data and accounting for biochemical properties driving TCR-peptide-HLA binding specificity, HLA-Arena can help facilitate the design of better and safer cancer vaccines and T-cell-based immunotherapies for patients with different types of cancers.
NCI’s Informatics Technology for Cancer Research Program funds HLA-Arena.
Dr. Antunes is the assistant professor of computational biology in the Department of Biology and Biochemistry at the University of Houston.
Upcoming Events
- Agentic AI in Cancer ResearchMay 27, 2025BTEC 2025 Annual Conference: The Epidemiology of Brain Metastases for Adult and Pediatric Brain TumorsMay 29, 2025Ctrl+Alt+Cure: Driving Smarter Cancer CareJune 11, 2025NCI Emerging Technologies Seminar: Programs and Resources to Support Technology Development for Cancer ResearchJune 17, 2025Data Jamboree: Enhancing Childhood Cancer Data Sharing and UtilitySeptember 29, 2025 - September 30, 2025NCI Office of Data Sharing’s Annual Data Sharing Symposium 2025: How Data Advances the Impact of Cancer ResearchSeptember 30, 2025 - October 01, 2025