The Exploration of Pan-Cancer Dysregulated Pathways and PolyTherapy AI
The August NCI Cancer Research Data Commons (CRDC) Cancer Genomics Cloud (CGC) webinar will feature a presentation from bioinformatics consultant and CGC Collaborative Project Award recipient Margaret Liñán. She will share how her work with the Arizona State’s Translational Genomics Lab leveraged the CGC’s cloud-based access to perform pan-cancer studies.
During the event, Ms. Liñán will discuss her collaboration’s current and pan-cancer research study efforts, including:
- the detection and ranking of mRNA dysregulated pathways using the Pathways of Topological Rank Analysis (PoTRA) tool with normalized TCGA data from the CGC.
- the identification of rank dispersion drivers in mRNA mediated dysregulated pathways from invasive breast cancer
- the development of an interactive artificial intelligence platform, PolyTherapy AI, for multi-omics combination drug treatment.
As one of the three Cloud Resources within the NCI CRDC, the Seven Bridges’ CGC provides researchers access to a wide variety of data sets, a catalog of tools to analyze and visualize the data directly from the browser, and scalable computational resources to perform large-scale analysis on the cloud.
Ms. Liñán is a bioinformatics consultant currently collaborating with Dr. Valentin Dinu’s Translational Genomics Lab at the College of Health Solutions – Arizona State University and others in academia and industry.
Upcoming Events
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Predicting Patients’ Response to Immunotherapy from Tumor Histopathology and Blood: Computational Science in Immuno-oncologyJuly 08, 2025Data Jamboree: Enhancing Childhood Cancer Data Sharing and UtilitySeptember 29, 2025 - September 30, 2025NCI Office of Data Sharing’s Annual Data Sharing Symposium 2025: How Data Advances the Impact of Cancer ResearchSeptember 30, 2025 - October 01, 2025Childhood Cancer Data Initiative (CCDI) Symposium 2025October 06, 2025 - October 07, 2025