The Exploration of Pan-Cancer Dysregulated Pathways and PolyTherapy AI
The August NCI Cancer Research Data Commons (CRDC) Cancer Genomics Cloud (CGC) webinar will feature a presentation from bioinformatics consultant and CGC Collaborative Project Award recipient Margaret Liñán. She will share how her work with the Arizona State’s Translational Genomics Lab leveraged the CGC’s cloud-based access to perform pan-cancer studies.
During the event, Ms. Liñán will discuss her collaboration’s current and pan-cancer research study efforts, including:
- the detection and ranking of mRNA dysregulated pathways using the Pathways of Topological Rank Analysis (PoTRA) tool with normalized TCGA data from the CGC.
- the identification of rank dispersion drivers in mRNA mediated dysregulated pathways from invasive breast cancer
- the development of an interactive artificial intelligence platform, PolyTherapy AI, for multi-omics combination drug treatment.
As one of the three Cloud Resources within the NCI CRDC, the Seven Bridges’ CGC provides researchers access to a wide variety of data sets, a catalog of tools to analyze and visualize the data directly from the browser, and scalable computational resources to perform large-scale analysis on the cloud.
Ms. Liñán is a bioinformatics consultant currently collaborating with Dr. Valentin Dinu’s Translational Genomics Lab at the College of Health Solutions – Arizona State University and others in academia and industry.