Example Use Cases for Harmonized Data in the GDC

During this webinar, the Genomic Data Commons’ (GDC’s) Drs. Zhenyu Zhang and Bill Wysocki will review the different types of harmonized data that the GDC makes available for the cancer research community. The webinar will also:

• exemplify use cases for this data, such as how to:
  • identify high- and low-frequency cancer drivers.
  •  define genomic determinants of response to therapy.
  •  inform the composition of clinical trial cohorts that shared targeted genetic lesions.
•  provide an overview of GDC pipelines for harmonizing and processing data.

The NCI GDC harmonizes raw sequencing data from cancer genomic studies by aligning to a common reference genome and applying standard bioinformatics pipelines. This generates high-level data such as mutation calls and structural variants.

As part of the NCI Cancer Research Data Commons (CRDC), the GDC provides the cancer research community with data and tools to access, analyze, and share valuable genomic data.