Dynamics of 3D Genome Structure and Function

Join MIT’s Dr. Anders Hansen as he discusses the high-resolution imaging tools that his team developed to study the 3D structure of the human genome and understand how changes in the structure cause oncogene overexpression in cancer.

To analyze the images their new experimental method collects, his group also developed a new method for the computational analysis of the human genome. They developed an image processing framework, “ConnectTheDots,” and modeling software, “Bayesian Inference of Loop Dynamics” (or ‘BILD’), to analyze the spatiotemporal dynamics collected through the imaging platform and infer which segments of DNA are in the looped state.