This session will provide information about CPTAC's comprehensive proteomic and matching genomic tumor characterization methodologies, data access procedures, informatics tools for proteogenomics analysis, and recent advances on mass spectrometry-based targeted assays.

Using data sets from the Human Cell Atlas (HCA), combined with tools and computational resources available on the Cancer Genomics Cloud (CGC), the Seven Bridges team describe changes in transcriptome profiles of endothelial tumor cells over time. They demonstrate the importance of developing reproducible workflows that can run in multiple environments, and show how existing data can offer new insight into today’s complex biological questions.

The presentation gives an overview of the Proteomic Data Commons (PDC) and its available data sets, and describes how the PDC facilitates multi-omic data analyses.

The Seven Bridges team describe how new features of the Cancer Genomics Cloud (CGC) have been implemented to broaden the data and workflows accessible to cancer researchers, including integration with NCI's Cancer Research Data Commons (CRDC).