Seminar Series
Headshot of Obi Griffith, Ph.D.
June 15, 2022 11:00 a.m. - 12:00 p.m. ET

Obi L. Griffith, Ph.D.

Dr. Obi L. Griffith will discuss CIViC, an open access, open source, community-driven web resource for clinical interpretation of variants in cancer. The goal of this resource is to enable precision medicine by providing an educational forum for dissemination of knowledge and active discussion of the clinical significance of cancer genome alterations.

Headshot of Svitlana Volkova
June 01, 2022 11:00 a.m. - 12:00 p.m. ET

Svitlana Volkova, Ph.D.

Dr. Svitlana Volkova will discuss a suite of augmented intelligence solutions powered by Artificial Intelligence models. She’ll show how these models can be used to detect, anticipate, and reason with technical expertise and capability development to analyze and extract knowledge from large amounts of unstructured scientific literature data.

Clemens Grassberge
April 20, 2022 11:00 a.m. - 12:00 p.m. ET

Clemens Grassberger, Ph.D.

Dr. Grassberger will highlight the current computational and mathematical approaches for modeling the impact of radiotherapy on the immune system, as well as designing the next generation of combination trials.

Headshot of Malachi Griffith
April 06, 2022 11:00 a.m. - 12:00 p.m. ET

Malachi Griffith, Ph.D.

Dr. Malachi Griffith will give an introduction to neoantigens, a promising area for cancer immunotherapy and precision medicine. Dr. Griffith will describe how immunogenomic and bioinformatic approaches are helping to identify neoantigens and therapeutic modalities to target these abnormal proteins. He also will offer insight into tools to support related clinical trial efforts.

Headshot of Ben Raphael
March 23, 2022 11:00 a.m. - 12:00 p.m. ET

Ben Raphael, Ph.D.

Dr. Ben Raphael will describe how tumors are heterogeneous mixtures of normal and cancerous cells with distinct genetic and transcriptional profiles. He’ll also discuss computational approaches to quantify tumor heterogeneity and reconstruct tumor evolution using data from single-cell DNA and spatial RNA sequencing technologies.

Headshot of Elana Fertig, Ph.D.
March 09, 2022 11:00 a.m. - 12:00 p.m. ET

Elana J. Fertig, Ph.D.

Dr. Elana J. Fertig (whose lab also uses multiplatform genomics data, blended with mathematical modeling and artificial intelligence) will demonstrate how CoGAPS, an established method for identifying transcriptional signatures related to cell type and state, can be applied to single cell data to identify patterns underlying immunotherapy response and resistance. Combining CoGAPS with transfer learning approaches provides insight into the patterns found in preclinical models, which then can be applied to patient samples to find shared features across data sets from different species.

Headshot of Eliezer Van Allen, M.D.
April 21, 2021 11:00 a.m. - 12:00 p.m. ET

Dr. Eliezer Van Allen

Dr. Eliezer Van Allen will describe how a patient’s cancer genome can be used to guide individualized treatment choices for precision medicine. He will examine how to identify treatment resistance mechanisms and show how certain phenotypic patterns can be paired with new modes of computation to further inform treatment decisions.

Headshot of Charles Wang, M.D., Ph.D.
April 07, 2021 11:00 a.m. - 12:00 p.m. ET

Charles Wang, M.D., Ph.D., M.P.H.

Dr. Charles Wang will address the need for guidance in selecting algorithms for accurate biological interpretations of varied data types acquired with different single-cell RNA sequencing platforms.

Headshot of Noemie Elhadad, Ph.D.
January 13, 2021 11:00 a.m. - 12:00 p.m. ET

Noémie Elhadad, Ph.D.

Dr. Noémie Elhadad will show how patient-record summation tools can help clinicians make sense of seemingly overwhelming amounts of patient data at the point of care.

Dr. Nicolas Fernandez
December 02, 2020 11:00 a.m. - 12:00 p.m. ET

Nicolas Fernandez, Ph.D.

Dr. Nicolas Fernandez will demonstrate the latest version of Clustergrammer2, a visualization tool that allows users to perform more refined clustering on cell lines and genes.