Structure of the Abl protein kinase catalytic domain bound to a first-generation therapeutic, imatinib (PDB ID 1IEP; orange), which inspired medicinal chemists at Novartis to design an even more effective second-generation agent, nilotinib (PDB ID 3CS9; green). Both are U.S. FDA approved drugs used for treatment of chronic myeloid leukemiaRutgers, The State University of New Jersey
As of today, the 2023 Data Management and Sharing (DMS) Policy has gone into effect. Find out what you will need to do.