"Image of circular plot with 6 wedges containing dots that show the cancer types of the TCGA tumor samples that exhibit this mutation with the numbers of mutations (mutations/Mb) increasing as the number of dots move to the edge of the wedge. Wedge 1, Mutation C->T: (from outer edge to center): Melanoma, Lung Adenocarcinoma, Acute Myeloid Leukemia, Breast cancer, Prostate Cancer, Thyroid Cancer. Wedge 2, Mutation C->A: Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Head and Neck cancer, Ewing Sarcoma, Chronic Lymphocytic Leukemia, Ovarian Cancer, Thyroid Cancer, Diffuse large B-cell lymphoma Wedge 3, Mutation Tp*A->T: Acute Myeloid Leukemia, Ovarian Cancer, Chronic Lymphocytic Leukemia, Diffuse Large B-cell Lymphoma Wedge 4, Mutation misc: Acute Myeloid Leukemia, Esophageal Adenocarcinoma, Bladder Cancer, Breast Cancer, Lung adenocarcinoma, Lung Squamous Cell Carcinoma, Glioblastoma Multiforme, Ewing Sarcoma, Ovarian, Low-grade Glioma, Chronic Lymphocytic Leukemia Wedge 5, Mutation *CpG->T: Colorectal, Esophageal Adenocarcinoma, Low-grade Glioma, Stomach, Lung Adenocarcinoma, Head and Neck, EWING Sarcoma, Kidney Clear Cell, Glioblastoma Multiforme, Pancreas, Prostate, Rhabdoid Tumor, Kidney Papillary Cell Wedge 6, Mutation: Tp*C->mut: Bladder, Cervical, Head and Neck, Lung Squamous Cell CARCINOMA, Breast Cancer, Prostate, Head and Neck, Ovarian, Kidney Clear Cell, Kidney Papillary Cell, Melanoma, Pancreas"

This figure shows the mutational spectrum of a sample of tumors from TCGA on a circular plot. By visualizing data in this way, researchers can see the natural groupings of tumors according to where they fall along a mutational spectrum. (Lawrence MS, Stojanov P, Polak P, et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013;499(7457):214-218. doi:10.1038/nature12213.)