Five large round circles show key steps in creating a workflow using KnowENG tools. The circles represent “Gene Set Characterization Workflow,” “Gene Set Characterization Workflow,” “Gene Prioritization Workflow,” “Signature Analysis Workflow,” and “Spreadsheet Builder.” To the left are items that feed into the workflows, including “Input Files,” “Signature Files,” “Gene Set Property Network Edge Type,” “Knowledge Network Edge Type,” and “Amount of Network Influence.” To the right, are the results of these workflows, including “GSC DRaWR Results, “GSC Fisher Results,” “Top Genes File, Clean Genomic Matrix,” and Clean Phenotypic Matrix.”