The National Human Genome Research Institute (NHGRI) has launched a new program called the Impact of Genomic Variation on Function (IGVF) Consortium. Organized as a research consortium, IGVF will bring investigators together to examine how genomes function, how genome function shapes phenotypes, and how these processes are influenced by genomic variation. The program will utilize emerging experimental and computational genomic approaches to build a catalog of the impact of genomic variants on genome function and phenotypes.  

NHGRI strongly encourages all investigators with innovative ideas aligned with IGVF goals to submit applications, especially investigators from demographic groups or institutions generally underrepresented in genomic science, new investigators, experienced investigators who are new to genomic science, and investigators who have not previously participated in a NHGRI consortium or program. Such investigators will be supported through five Funding Opportunity Announcements (FOAs):

• Systematic Characterization of Genomic Variation on Genome Function and Phenotype (UM1 Clinical Trial Not Allowed) (RFA-HG-20-043)
• Defining Genomic Influence on Gene Network Regulation (U01 Clinical Trial Not Allowed) (RFA-HG-20-044)
• Single-cell Profiling of Regulatory Element and Gene Activity in Relationship to Genome Function (UM1 Clinical Trial Not Allowed) (RFA-HG-20-045)
• Genomic Variation and Function Data and Administrative Coordinating Center (U24 Clinical Trial Not Allowed) (RFA-HG-20-046)
• Developing Predictive Models of the Impact of Genomic Variation on Function (U01 Clinical Trial Not Allowed) (RFA-HG-20-047)

For more information, attend a pre-application webinar on either September 3 or 9, 2020. Please see the NIH Office of Extramural Research webpage for additional webinar details.