The Childhood Cancer Data Initiative (CCDI) has recently granted administrative supplements to eight NCI-Designated Cancer Centers. With this funding, the centers’ project teams are to study the data within the CCDI Data Ecosystem and determine how it can be used to promote better research collaboration and propel new discoveries in treatment and care. New scientific questions and cutting-edge analytical tools could also be identified from the work of these projects.

The eight funded projects and their corresponding institutions are as follows:

• “Creating the Childhood Cancer Isoform Atlas: Informatics Tools and Multi-Omics Insights for Immunotherapy Targets” | Abramson Cancer Center, University of Pennsylvania
• “Real-World Molecularly Targeted Treatment Registry (MaTTeR): A Pilot Study to Enrich CCDI Data Utilizing Directed Electronic Medical Record Extraction” | Boston Children’s Hospital and Dana-Farber Cancer Institute
• “Enhancing Precision of Pediatric Cancer Molecular Targets by Aggregating CCDI Genomic Data to Pediatric Cancer Knowledgebase” | Comprehensive Cancer Center, St. Jude Children’s Research Hospital
• “Machine Learning Framework for Accurate Childhood Acute Myeloid Leukemia Subtype Identification” | Fred & Pamela Buffett Cancer Center, University of Nebraska
• “Automated Classification of Pediatric Soft Tissue Sarcoma from Histopathology Images” | The Jackson Laboratory
• “Unlocking the Potential of Extrachromosomal Circular DNA (eccDNA) as Prognostic Markers in Childhood and Adolescents and Young Adults (AYA) Cancers” | Sanford Burnham Prebys Medical Discovery Institute
• “Enhancing Pediatric Cancer Research with AI-Driven Diagnostics” | USC Norris Comprehensive Cancer Center, University of Southern California and Children’s Hospital Los Angeles
• “Leveraging ExtractEHR and Fast Healthcare Interoperability Resources (FHIR) Framework for Enhancing Clinical Data Integration” | Winship Cancer Institute, Emory University, and Children’s Hospital of Philadelphia

“These administrative supplements provide Cancer Centers with additional resources to collaborate, enabling them to aggregate, integrate, analyze, and visualize pediatric cancer data from diverse sources,” says Subhashini Jagu, lead for the CCDI Ecosystem. “This process helps uncover potential avenues for therapeutic translation.”