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CPTAC Researchers Expand Use of MSFragger to Identify N- and O-linked Glycopeptides

Depiction of lightning bolts showering down upon an illuminated city. The bolts issue from a large "cloud" that reads "MSFragger Glyco."

Clinical Proteomic Tumor Analysis Consortium (CPTAC) researchers from the Nesvizhskii Lab at the University of Michigan have developed an extension of their MSFragger flagship software. MSFragger is an ultrafast database search tool that identifies peptides and their modified forms in mass spectrometry-based proteomics.

This new software, MSFragger-Glyco, identifies N- and O-linked glycopeptides and allows researchers to have the same ultrafast and sensitive search for glycopeptide spectrum matches as with the original MSFragger software.

The broader impact of this work helps cancer researchers further identify even more glyco-modifications that have a strong or direct impact on tumor development.

Detailed information about the software and its use can be found at the Office of Cancer Clinical Proteomics Research website.