Qingrong Chen, Ph.D.
Project Manager
Contact Information
Biography
Dr. Qingrong Chen joined CBIIT in 2011 and currently serves as a project manager and biomedical informatics specialist with the Computational Genomics and Bioinformatics Group in the Informatics and Data Science Program. Prior to her appointment at CBIIT, Dr. Chen worked as a senior computational biologist in the NCI Center for Cancer Research. She has co-authored over 70 papers in peer-reviewed journals, covering bioinformatics and next generation sequencing data analysis. She received her medical degree from the Zhejiang University School of Medicine and her doctorate in philosophy from Showa University.
Projects
- APOLLO
- Application Support
- The Cancer Genome Atlas (TCGA)
- Therapeutically Applicable Research to Generate Effective Treatments (TARGET)
Publications
- Molecular Profiling of Exceptional Responders to Cancer Therapy. Bilusic M, Girardi D, Zhou Y, Jung K, Pei J, Slifker M, Chen Q, Meerzaman D, Alpaugh K, Young D, Flieder D, Gray P, Plimack E. Oncologist. 2021 Mar;26(3):186-195. doi: 10.1002/onco.13600. Epub 2020 Nov 28. PMID: 33210795 Free PMC article.
- Cross-Site Concordance Evaluation of Tumor DNA and RNA Sequencing Platforms for the CIMAC-CIDC Network. Zeng Z, Fu J, Cibulskis C, Jhaveri A, Gumbs C, Das B, Sanchez-Espiridion B, Janssens S, Taing L, Wang J, Lindsay J, Vilimas T, Zhang J, Tokheim C, Sahu A, Jiang P, Yan C, Duose DY, Cerami E, Chen L, Cohen D, Chen Q, Enos R, Huang X, Lee JJ, Liu Y, Neuberg DS, Nguyen C, Patterson C, Sarkar S, Shukla S, Tang M, Tsuji J, Uduman M, Wang X, Weirather JL, Yu J, Yu J, Zhang J, Zhang J, Meerzaman D, Thurin M, Futreal A, Karlovich C, Gabriel SB, Wistuba II, Liu XS, Wu CJ. Clin Cancer Res. 2020 Dec 15:clincanres.3251.2020. doi: 10.1158/1078-0432.CCR-20-3251. Online ahead of print. PMID: 33323402
- The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing. Uppal S, Gegonne A, Chen Q, Thompson PS, Cheng D, Mu J, Meerzaman D, Misra HS, Singer DS. Cell Rep. 2019 Nov 19;29(8):2450-2460.e5. doi: 10.1016/j.celrep.2019.10.066. PMID: 31747612 Free PMC article.
- Comparing the performance of selected variant callers using synthetic data and genome segmentation. Bian X, Zhu B, Wang M, Hu Y, Chen Q, Nguyen C, Hicks B, Meerzaman D. BMC Bioinformatics. 2018 Nov 19;19(1):429. doi: 10.1186/s12859-018-2440-7. PMID: 30453880 Free PMC article.
- Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation. Gegonne A, Chen QR, Dey A, Etzensperger R, Tai X, Singer A, Meerzaman D, Ozato K, Singer DS. Cell Rep. 2018 Jul 3;24(1):117-129. doi: 10.1016/j.celrep.2018.06.007. PMID: 29972774 Free PMC article.
- A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor. Gadd S, Huff V, Walz AL, Ooms AHAG, Armstrong AE, Gerhard DS, Smith MA, Auvil JMG, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Hermida LC, Davidsen T, Gesuwan P, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Dome JS, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Ross N, Gastier-Foster JM, Arold ST, Perlman EJ. Nat Genet. 2017 Oct;49(10):1487-1494. doi: 10.1038/ng.3940. Epub 2017 Aug 21. PMID: 28825729 Free PMC article.
- Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study. Shi J, Hua X, Zhu B, Ravichandran S, Wang M, Nguyen C, Brodie SA, Palleschi A, Alloisio M, Pariscenti G, Jones K, Zhou W, Bouk AJ, Boland J, Hicks B, Risch A, Bennett H, Luke BT, Song L, Duan J, Liu P, Kohno T, Chen Q, Meerzaman D, Marconett C, Laird-Offringa I, Mills I, Caporaso NE, Gail MH, Pesatori AC, Consonni D, Bertazzi PA, Chanock SJ, Landi MT. PLoS Med. 2016 Dec 6;13(12):e1002162. doi: 10.1371/journal.pmed.1002162. eCollection 2016 Dec. PMID: 27923066 Free PMC article.
- BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin. Devaiah BN, Case-Borden C, Gegonne A, Hsu CH, Chen Q, Meerzaman D, Dey A, Ozato K, Singer DS. Nat Struct Mol Biol. 2016 Jun;23(6):540-8. doi: 10.1038/nsmb.3228. Epub 2016 May 9. PMID: 27159561 Free PMC article.
- Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group. Ooms AH, Gadd S, Gerhard DS, Smith MA, Guidry Auvil JM, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Huff V, Dome JS, Chi YY, Tian J, Geller JI, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Walz AL, van den Heuvel-Eibrink MM, de Krijger RR, Ross N, Gastier-Foster JM, Perlman EJ. Clin Cancer Res. 2016 Nov 15;22(22):5582-5591. doi: 10.1158/1078-0432.CCR-16-0985. Epub 2016 Oct 4. PMID: 27702824 Free PMC article.
- Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. Walz AL, Ooms A, Gadd S, Gerhard DS, Smith MA, Guidry Auvil JM, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Bowlby R, Brooks D, Ma Y, Mungall AJ, Moore RA, Schein J, Marra MA, Huff V, Dome JS, Chi YY, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Jafari N, Ross N, Gastier-Foster JM, Perlman EJ. Cancer Cell. 2015 Feb 9;27(2):286-97. doi: 10.1016/j.ccell.2015.01.003. PMID: 25670082 Free PMC article.