Pediatric Genomic Data Inventory
Pediatric, adolescent and young adult (AYA) cancer data is a valuable resource in cancer research data science. 
Pediatric and AYA cancer is a genetically driven disease, but the genomic data for this age group is critically limited. Many Pediatric and AYA cancers are different from cancer in adults, and as a result, it is difficult to understand which treatments and diagnosis methods are best for patients in this age group.
To fuel new discoveries and treatments, NCI developed a dynamic resource known as the Pediatric Genomic Data Inventory (PGDI) to help investigators locate genomic data sets more easily. This resource lists known ongoing and completed sequencing projects of pediatric cancer cohorts from the United States and other countries, along with some basic details and reference metadata. The success of this resource requires ongoing participation from the research community. Feedback about this resource is both welcomed and encouraged. For questions about the data listed in the table, please email the NCI Office Of Data Sharing.
Download the full spreadsheet.
| Project Name | Cancer Type | Cancer Data Available | Primary Publications | Principle Investigator |
|---|---|---|---|---|
| Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors - Synovial Sarcoma | Malignant neoplasm of other connective and soft tissue | N/A |
|
Katherine Janeway |
| Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors - Undifferentiated Sarcoma | Malignant neoplasm of other and ill-defined sites | N/A | Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors |
Katherine Janeway |
| Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors - Wilms Tumor | Malignant neoplasm of the Kidney | N/A | Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors |
Katherine Janeway |
| Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors – Neuroblastoma | Malignant neoplasm of adrenal gland | N/A | Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors |
Katherine Janeway |
| Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors – Osteosarcoma | Malignant neoplasm of bone and articular cartilage of limbs | N/A | Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors |
Katherine Janeway |
| Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors – Rhabdomyosarcoma | Malignant neoplasm of other connective and soft tissue | N/A | Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors |
Katherine Janeway |
| International Cancer Genome Consortium (ICGC) Pediatric Brain Tumor (PedBrain) Medulloblastoma (MB) | Malignant neoplasm of brain | N/A | Stefan M. Pfister | |
| International Cancer Genome Consortium (ICGC) Pediatric Brain Tumor (PedBrain) Pediatric Glioblastoma | Malignant neoplasm of brain |
Recurrent MET Fusion Genes
|
Stefan M. Pfister | |
| International Cancer Genome Consortium (ICGC) Pediatric Brain Tumor (PedBrain) Pilocytic Astrocytoma | Malignant neoplasm of brain |
Recurrent Somatic Alterations |
Stefan M. Pfister | |
| International Neuroblastoma Risk Group (INGR) | Malignant neoplasm of peripheral nerves and autonomic nervous system Malignant neoplasm of adrenal gland |
The International Neuroblastoma Risk Group (INRG) |
Sam Volchenboum | |
| International Soft Tissue Sarcoma Consortium (INSTRuCT) | Malignant neoplasm of other connective and soft tissue | N/A | Sam Volchenboum | |
| Pediatric Cancer Genome Project (PCGP) - Acute Lymphoblastic Leukemia (ALL) | Lymphoid leukemia | N/A |
Rise and Fall of Subclones From Diagnosis |
|
| Pediatric Cancer Genome Project (PCGP) - ATRX | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - Adrenocortical Tumor (ACT) | Malignant neoplasm of adrenal gland |
European Genome-phenome Archive Data Set Accession: EGAD00001000160 |
|
|
| Pediatric Cancer Genome Project (PCGP) - AMLM7 | Other leukemias of specified cell type | N/A | James R. Downing | |
| Pediatric Cancer Genome Project (PCGP) - BALL-PAX5 | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - Core-Binding Factor (CBF) Acute Myeloid Leukemia | Myeloid leukemia |
The Genomic Landscape of Core-Binding Factor Acute Myeloid Leukemias |
||
| Pediatric Cancer Genome Project (PCGP) - C | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - E2A | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - Ependymoma (EPD) | Neoplasm of uncertain behavior of brain and central nervous system |
European Genome-phenome Archive Data Set Accession: EGAD00001000162
|
C11orf95-RELA Fusions Drive Oncogenic NF-κB Signalling In Ependymoma |
|
| Pediatric Cancer Genome Project (PCGP) - ERG | Lymphoid leukemia |
Deregulation of DUX4 and ERG In Acute Lymphoblastic Leukemia
|
||
| Pediatric Cancer Genome Project (PCGP) - ERG2 | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - ETV | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - EWS | Malignant neoplasm of bone and articular cartilage of other and unspecified sites | N/A | ||
| Pediatric Cancer Genome Project (PCGP) - High Grade Glioblastoma (HGG) | Malignant neoplasm of brain |
European Genome-phenome Archive Data Set Accession: EGAD00001000085
|
||
| Pediatric Cancer Genome Project (PCGP) - Histone | Other leukemias of specified cell type | N/A | ||
| Pediatric Cancer Genome Project (PCGP) - HYPER | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - Hypodiploid Acute Lymphoblastic Leukemia (HYPO) | Lymphoid leukemia |
The Genomic Landscape Of Hypodiploid Acute Lymphoblastic Leukemia |
Charles G. Mullighan | |
| Pediatric Cancer Genome Project (PCGP) - Infant Acute Lymphoblastic Leukemia (INF) | Lymphoid leukemia |
European Genome-phenome Archive Data Set Accession: EGAD00001000165 |
The Landscape Of Somatic Mutations In Infant MLL-rearranged Acute Lymphoblastic Leukemias |
|
| Pediatric Cancer Genome Project (PCGP) - Low Grade Glioma (LGG) | Malignant neoplasm of brain |
European Genome-phenome Archive Data Set Accession: EGAD00001000161 |
|
David W. Ellison |
| Pediatric Cancer Genome Project (PCGP) - Medulloblastoma (MB) | Malignant neoplasm of brain |
|
||
| Pediatric Cancer Genome Project (PCGP) - Melanoma (MEL) | Malignant melanoma of skin | N/A | ||
| Pediatric Cancer Genome Project (PCGP) - Osteosarcoma (OS) | Malignant neoplasm of bone and articular cartilage of other and unspecified sites |
European Genome-phenome Archive Data Set Accession: EGAD00001000159 |
Recurrent Somatic Structural Variations Contribute To Tumorigenesis In Pediatric Osteosarcoma Recurrent Somatic Structural Variations Contribute To Tumorigenesis In Pediatric Osteosarcoma
|
|
| Pediatric Cancer Genome Project (PCGP) - PHALL | N/A | N/A | N/A | N/A |
| Pediatric Cancer Genome Project (PCGP) - Ph-like Acute Lymphoblastic Leukemia (Ph-like ALL) | Lymphoid leukemia |
European Genome-phenome Archive Data Set Accession: EGAS00001000654 |
Targetable Kinase-activating Lesions In Ph-like Acute Lymphoblastic Leukemia Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia |
Charles G. Mullighan |
| Pediatric Cancer Genome Project (PCGP) - Retinoblastoma (RB) | Malignant neoplasm of eye and adnexa |
European Genome-phenome Archive Data Set Accession: EGAD00001000261 |
A Novel Retinoblastoma Therapy From Genomic And Epigenetic Analyses Coexpression Of Normally Incompatible Developmental Pathways In Retinoblastoma Genesis |
|
| Pediatric Cancer Genome Project (PCGP) - Rhabdomyosarcoma (RHB) | Malignant neoplasm of other connective and soft tissue |
European Genome-phenome Archive Data Set Accession: EGAD00001000164 |
Michael A. Dyer | |
| Pediatric Cancer Genome Project (PCGP) - T-cell Acute Lymphoblastic Leukemia (TALL) | Lymphoid leukemia |
The Genetic Basis Of Early T-cell Precursor Acute Lymphoblastic Leukaemia CREST Maps Somatic Structural Variation In Cancer Genomes With Base-pair Resolution |
||
| The Genomic Landscape of Tuberous Sclerosis Complex (TSC) | Malignant neoplasm of brain Malignant neoplasm of kidney, except renal pelvis Malignant neoplasm of heart, mediastinum and pleura Other and unspecified malignant neoplasm of skin |
Database of Genotypes and Phenotypes Accession: phs001357.v1.p1 |
Jeffrey P. MacKeigan | |
| Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Clear Cell Sarcoma of the Kidney (CCSK) | Malignant neuroendocrine tumors |
TCF21 Hypermethylation In Genetically Quiescent Clear Cell Sarcoma Of The Kidney |
Elizabeth J. Perlman | |
| Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Osteosarcoma (OS) | Malignant neoplasm of bone and articular cartilage of other and unspecified sites | Target Data Matrix | In Progress | |
| Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Phase I Acute Lymphoblastic Leukemia (ALL) | Lymphoid leukemia | Target Data Matrix |
Deletion of IKZF1 And Prognosis In Acute Lymphoblastic Leukemia |
|
| Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Phase II Acute Lymphoblastic Leukemia (ALL) | Lymphoid leukemia | Target Data Matrix | In Progress | |
| Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Rhabdoid Tumor (RT) | Malignant neuroendocrine tumors | Target Data Matrix | Elizabeth J. Perlman | |
| Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Wilms Tumor (WT) | Malignant neoplasm of adrenal gland | Target Data Matrix | Submitted | Elizabeth J. Perlman |