Pediatric Genomic Data Inventory

Pediatric, adolescent and young adult (AYA) cancer data is a valuable resource in cancer research data science. Child sitting on swing Pediatric and AYA cancer is a genetically driven disease, but the genomic data for this age group is critically limited. Many Pediatric and AYA cancers are different from cancer in adults, and as a result, it is difficult to understand which treatments and diagnosis methods are best for patients in this age group.

To fuel new discoveries and treatments, NCI developed a dynamic resource known as the Pediatric Genomic Data Inventory (PGDI) to help investigators locate genomic data sets more easily. This resource lists known ongoing and completed sequencing projects of pediatric cancer cohorts from the United States and other countries, along with some basic details and reference metadata. The success of this resource requires ongoing participation from the research community. Feedback about this resource is both welcomed and encouraged. For questions about the data listed in the table, please email the NCI Office Of Data Sharing.

Download the full spreadsheet.

Project Name	Cancer Type	Cancer Data Available	Primary Publications	Principal Investigator
Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors - Synovial Sarcoma	Malignant neoplasm of other connective and soft tissue	N/A	Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors	Katherine Janeway
Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors - Undifferentiated Sarcoma	Malignant neoplasm of other and ill-defined sites	N/A	Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors	Katherine Janeway
Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors - Wilms Tumor	Malignant neoplasm of the Kidney	N/A	Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors	Katherine Janeway
Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors – Neuroblastoma	Malignant neoplasm of adrenal gland	N/A	Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors	Katherine Janeway
Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors – Osteosarcoma	Malignant neoplasm of bone and articular cartilage of limbs	N/A	Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors	Katherine Janeway
Individualized Cancer Therapy (iCat) Recommendation for Patients with Relapsed, Refractory, or High-Risk Solid Tumors – Rhabdomyosarcoma	Malignant neoplasm of other connective and soft tissue	N/A	Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors	Katherine Janeway
International Cancer Genome Consortium (ICGC) Pediatric Brain Tumor (PedBrain) Medulloblastoma (MB)	Malignant neoplasm of brain	N/A	The Whole-genome Landscape of Medulloblastoma Subtypes	Stefan M. Pfister
International Cancer Genome Consortium (ICGC) Pediatric Brain Tumor (PedBrain) Pediatric Glioblastoma	Malignant neoplasm of brain	https://dcc.icgc.org/	Recurrent MET Fusion Genes Represent A Drug Target In Pediatric Glioblastoma	Stefan M. Pfister
International Cancer Genome Consortium (ICGC) Pediatric Brain Tumor (PedBrain) Pilocytic Astrocytoma	Malignant neoplasm of brain	https://dcc.icgc.org/	Recurrent Somatic Alterations Of FGFR1 And NTRK2 in Pilocytic Astrocytoma	Stefan M. Pfister
International Neuroblastoma Risk Group (INGR)	Malignant neoplasm of peripheral nerves and autonomic nervous system Malignant neoplasm of adrenal gland	INRG Data Commons	The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report	Sam Volchenboum
International Soft Tissue Sarcoma Consortium (INSTRuCT)	Malignant neoplasm of other connective and soft tissue	INSTRuCT Cohort Discovery	N/A	Sam Volchenboum
Pediatric Cancer Genome Project (PCGP) - Acute Lymphoblastic Leukemia (ALL)	Lymphoid leukemia	N/A	Rise and Fall of Subclones From Diagnosis to Relapse in Pediatric B-Acute Lymphoblastic Leukaemia	Charles G. Mullighan Stephen P. Hunger Jinghui Zhang
Pediatric Cancer Genome Project (PCGP) - ATRX	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - Adrenocortical Tumor (ACT)	Malignant neoplasm of adrenal gland	European Genome-phenome Archive Data Set Accession: EGAD00001000160	Genomic Landscape of Paediatric Adrenocortical Tumours	Gerard P. Zambetti Raul C. Ribbeiro Jinghui Zhang
Pediatric Cancer Genome Project (PCGP) - AMLM7	Other leukemias of specified cell type	N/A	Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia	James R. Downing
Pediatric Cancer Genome Project (PCGP) - BALL-PAX5	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - Core-Binding Factor (CBF) Acute Myeloid Leukemia	Myeloid leukemia	European Genome-phenome Archive Data Set Accession: EGAD00001000268 European Genome-phenome Archive Data Set Accession: EGAS00001000349	The Genomic Landscape of Core-Binding Factor Acute Myeloid Leukemias	Lars Bullinger Jinghui Zhang Jeffery M. Klco James R. Downing
Pediatric Cancer Genome Project (PCGP) - C	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - E2A	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - Ependymoma (EPD)	Neoplasm of uncertain behavior of brain and central nervous system	European Genome-phenome Archive Data Set Accession: EGAD00001000162	C11orf95-RELA Fusions Drive Oncogenic NF-κB Signalling In Ependymoma	Richard J. Gilbertson David W. Ellison Jinghui Zhang
Pediatric Cancer Genome Project (PCGP) - ERG	Lymphoid leukemia	European Genome-phenome Archive Data Set Accession: EGAS00001001923 European Genome-phenome Archive Data Set Accession: EGAS00001000514 European Genome-phenome Archive Data Set Accession: EGAS00001000654	Deregulation of DUX4 and ERG In Acute Lymphoblastic Leukemia	Charles G. Mullighan Jinghui Zhang
Pediatric Cancer Genome Project (PCGP) - ERG2	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - ETV	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - EWS	Malignant neoplasm of bone and articular cartilage of other and unspecified sites	N/A	Genomic Landscape of Ewing Sarcoma Defines An Aggressive Subtype with Co-association of STAG2 and TP53 Mutations	Oliver Delattre Jinghui Zhang
Pediatric Cancer Genome Project (PCGP) - High Grade Glioblastoma (HGG)	Malignant neoplasm of brain	European Genome-phenome Archive Data Set Accession: EGAD00001000085	The Genomic Landscape Of Diffuse Intrinsic Pontine Glioma And Pediatric Non-brainstem High-grade Glioma Somatic Histone H3 Alterations in Pediatric Diffuse Intrinsic Pontine Gliomas And Non-brainstem Glioblastomas	Suzanne J. Baker Jinghui Zhang James R. Downing Richard K. Wilson
Pediatric Cancer Genome Project (PCGP) - Histone	Other leukemias of specified cell type	N/A	The Landscape of Somatic Mutations in Epigenetic Regulators Across 1,000 Paediatric Cancer Genomes Somatic Histone H3 Alterations In Pediatric Diffuse Intrinsic Pontine Gliomas and Non-brainstem Glioblastomas	Suzanne J. Baker Jinghui Zhang James R. Downing Richard K. Wilson
Pediatric Cancer Genome Project (PCGP) - HYPER	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - Hypodiploid Acute Lymphoblastic Leukemia (HYPO)	Lymphoid leukemia	European Genome-phenome Archive Data Set Accession: EGAD00001000260 Gene Expression Omnibus Accession: GSE38463	The Genomic Landscape Of Hypodiploid Acute Lymphoblastic Leukemia	Charles G. Mullighan
Pediatric Cancer Genome Project (PCGP) - Infant Acute Lymphoblastic Leukemia (INF)	Lymphoid leukemia	European Genome-phenome Archive Data Set Accession: EGAD00001000165	The Landscape Of Somatic Mutations In Infant MLL-rearranged Acute Lymphoblastic Leukemias	Anna K. Andersson Tanja A. Gruber James R. Downing
Pediatric Cancer Genome Project (PCGP) - Low Grade Glioma (LGG)	Malignant neoplasm of brain	European Genome-phenome Archive Data Set Accession: EGAD00001000161	Whole-genome Sequencing Identifies Genetic Alterations In Pediatric Low-grade Gliomas Genetic Alterations In Uncommon Low-grade Neuroepithelial Tumors: BRAF, FGFR1, And MYB Mutations Occur At High Frequency And Align With Morphology	David W. Ellison
Pediatric Cancer Genome Project (PCGP) - Medulloblastoma (MB)	Malignant neoplasm of brain	European Genome-phenome Archive Data Set Accession: EGAD00001000269 Gene Expression Omnibus Accession: GSE37418	Novel Mutations Target Distinct Subgroups Of Medulloblastoma ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy	Richard J. Gilbertson Jinghui Zhang James R. Downing Richard K. Wilson
Pediatric Cancer Genome Project (PCGP) - Melanoma (MEL)	Malignant melanoma of skin	N/A	The Genomic Landscape Of Childhood And Adolescent Melanoma	Alberto Pappo Armita Bahrami
Pediatric Cancer Genome Project (PCGP) - Osteosarcoma (OS)	Malignant neoplasm of bone and articular cartilage of other and unspecified sites	European Genome-phenome Archive Data Set Accession: EGAD00001000159	Recurrent Somatic Structural Variations Contribute To Tumorigenesis In Pediatric Osteosarcoma Recurrent Somatic Structural Variations Contribute To Tumorigenesis In Pediatric Osteosarcoma	Michael A. Dyer Jinghui Zhang
Pediatric Cancer Genome Project (PCGP) - PHALL	N/A	N/A	N/A	N/A
Pediatric Cancer Genome Project (PCGP) - Ph-like Acute Lymphoblastic Leukemia (Ph-like ALL)	Lymphoid leukemia	European Genome-phenome Archive Data Set Accession: EGAS00001000654	Targetable Kinase-activating Lesions In Ph-like Acute Lymphoblastic Leukemia Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia	Charles G. Mullighan
Pediatric Cancer Genome Project (PCGP) - Retinoblastoma (RB)	Malignant neoplasm of eye and adnexa	European Genome-phenome Archive Data Set Accession: EGAD00001000261 Gene Expression Omnibus Accession: GSE29686	A Novel Retinoblastoma Therapy From Genomic And Epigenetic Analyses Coexpression Of Normally Incompatible Developmental Pathways In Retinoblastoma Genesis	Michael A. Dyer James R. Downing Richard K. Wilson
Pediatric Cancer Genome Project (PCGP) - Rhabdomyosarcoma (RHB)	Malignant neoplasm of other connective and soft tissue	European Genome-phenome Archive Data Set Accession: EGAD00001000164	Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma	Michael A. Dyer
Pediatric Cancer Genome Project (PCGP) - T-cell Acute Lymphoblastic Leukemia (TALL)	Lymphoid leukemia	Database of Genotypes and Phenotypes Accession: phs000340.v3.p1 Gene Expression Omnibus Accession: GSE28703 Gene Expression Omnibus Accession: GSE3315	The Genetic Basis Of Early T-cell Precursor Acute Lymphoblastic Leukaemia CREST Maps Somatic Structural Variation In Cancer Genomes With Base-pair Resolution	James R. Downing Charles G. Mullighan
The Genomic Landscape of Tuberous Sclerosis Complex (TSC)	Malignant neoplasm of brain Malignant neoplasm of kidney, except renal pelvis Malignant neoplasm of heart, mediastinum and pleura Other and unspecified malignant neoplasm of skin	Database of Genotypes and Phenotypes Accession: phs001357.v1.p1	The Genomic Landscape Of Tuberous Sclerosis Complex	Jeffrey P. MacKeigan
Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Clear Cell Sarcoma of the Kidney (CCSK)	Malignant neuroendocrine tumors	Target Data Matrix	TCF21 Hypermethylation In Genetically Quiescent Clear Cell Sarcoma Of The Kidney	Elizabeth J. Perlman
Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Osteosarcoma (OS)	Malignant neoplasm of bone and articular cartilage of other and unspecified sites	Target Data Matrix	In Progress	Ching Lau Paul M. Meltzer
Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Phase I Acute Lymphoblastic Leukemia (ALL)	Lymphoid leukemia	Target Data Matrix	Deletion of IKZF1 And Prognosis In Acute Lymphoblastic Leukemia	Stephen P. Hunger Charles G. Mullighan Cheryl Willman
Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Phase II Acute Lymphoblastic Leukemia (ALL)	Lymphoid leukemia	Target Data Matrix	In Progress	Stephen P. Hunger Mignon Loh Charles G. Mullighan
Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Rhabdoid Tumor (RT)	Malignant neuroendocrine tumors	Target Data Matrix	Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways	Elizabeth J. Perlman
Therapeutically Applicable Research to Generate Effective Treatments (TARGET) - Wilms Tumor (WT)	Malignant neoplasm of adrenal gland	Target Data Matrix	Submitted	Elizabeth J. Perlman

Updated: Mar 03, 2021